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MINI: Doing work that matters

BioD + Z-SC1 MINI: DOING WORK THAT MATTERS NOVEL BIOLOGIC PRODUCTS DERIVED FROM THE PLACENTAL TISSUES This is the sort of  things that motivate us to continue with our innovation strategy. BioD is a company that is focused on making life better on earth. To properly achieve their mission, they need performing  equipment that they can rely on, right on the spot. We are proud to announce that BioD will supply with DF8503 TableTop / UnderCounter freezer, also known as MINI  to their clients for the storage of  the products they produce. Check out BioD’s work on development and commercialization of novel biologic products derived from the placental tissues. We would like to thank BSI for making this happen.


9,300-Year-Old Frozen Bison Mummy Found

In a previous post we explained how permafrost is the way of nature's keeping the temperature constantly low. Permafrost has helped scientists find all kinds of specimens from plants, animals and all the way to viruses, by keeping them in 'tip-top' shape for thousands of years. Working in the north east of Siberia, researchers recently found the most complete Bison mummy with all of its organs still intact and in a sleeping position which revealed that it probably died from starvation by the end of the ice age. This new work was presented at the annual Society of Vertebrate Paleontology meeting in November 2014 in Berlin and will be published in the Journal of Vertebrate Paleontology. Please read the post from IFLS here.


CHALLENGE ACCEPTED

Challenges are fun. They encourage us to deliver. Living in a 'challenge-oriented' philosophy will lead to a culture of experimentation in which we are requested to present the results which will sometimes  lead to great ideas or bold failures. But then you get the chance to have a new challenge and experiment again, push your limits and in the end, grow. It doesn't matter if you win or loose a challenge. What matters is to deliver. When you learn to deliver without postponing you will understand that major achievements come from doing. Failing or winning will just show you what to do more and what to do less. We want to share a couple of challenges: 1. Maxim & Katia Mezentsev created this beautiful video of freezing  nature. Some challenges do not come from elsewhere but from our necessity of moving away from the status quo. These kind of challenges will help you build your identity, your character. We love this video because, like we do, it thrives with the fact of an object in the freezing process. It's worth the look, the video lasts less than one minute and it was selected as a 'Vimeo Staff Picked'. Frozen from kveten on Vimeo. 2. The second challenge was one that our CEO, Jean Fallacara, decided to take : 'RECOVERY TESTING from a 2min Door Opening'.  He was very pleased when he received the results from the engineering team. Please read the post he wrote about it here. Challenges make us grow and define ourselves. We will continue delivering nice challenges we stumble upon with. We hope you enjoy as much as we do.    


ULT MONITORING SYSTEM: The Most Advanced

WiZBox creates the Ability to Predict ULT Freezer's Failure. The most advanced,  proactive, fault management system is finally here. And it's included for free with every Twincore. Think about how many samples have been lost in the recent history of science (Harvard Brain) because of the lack of ability to predict failure before it happens. Getting samples sometimes is not an easy task, but they can be lost when changes of temperature occur without notice. To right this wrong, we present (or developed) the Twincore and its Proactive maintenance device WizBox: The safest ult in the market, capable of maintaining -82 even when one of its 2 compressors fail. But we didn't stop there. We designed, and of course included, the most advanced monitoring system for the TwinCore. We are able to watch its behavior 24/7 and prevent any malfunction. ULT MONITORING SYSTEM: The most advanced yet! This system includes an app that lets you monitor your freezer's behavior from the palm of your hand. And not only that, this app features settings control and alarm history to name a few. We came out with a video. Please check it out here. For more information on the WizBox, click here.


Keeping temperature constant: Permafrost

Keeping temperature constant is not only our job. Nature has its own ways. "Permafrost exists where the ground stays at or below 0° Celsius (32° Fahrenheit) for at least two years in a row. 24 percent of the land in the Northern Hemisphere has permafrost underneath it. So, permafrost makes up 23 million square kilometers (9 million square miles). Large expanses of permafrost occur in Siberia, the Tibetan Plateau, Alaska, the Canadian Arctic, and other higher mountain regions. " National Snow & Ice Data Center Wherever civilization is built over Permafrost it's a priority to keep it that way. When it thaws it becomes a hazard which can cause landslides or ground subsidence. The roads become bumpy if not broken and buildings may fall apart. One way to keep it frozen is by drawing the heat from underground and vent it into the air above ground. A very simple device called a thermosyphon is up for the job. No electricity or maintenance required. Nature's stable permafrost not only presents certain conditions for developers. It also has helped scientists by keeping safe samples for years. We want to bring up this amazing story about 'bringing back to life' the 1918 flu virus which caused the most lethal plague in the history of human kind. It spread across the planet during the fall and disappeared by spring. To summarize the story, back in the 1950's Johan Hultin, a young scientist went off to find the virus on a victim buried (and conserved) in permafrost: nature's freezer. He did but he couldn't grow the flu virus. Hultin quit the mission, temporarily. 47 years later (1997) he heard about the initiative of Jeffery Taubenberger. another scientist looking for the virus but from the A.F.I.P.'s tissue repository. The new challenge was he was running out of raw material and that's when the connection was made. Hultin re-appeared to launch the new expedition to find the right samples. On the fourth day, they found the body of an obese woman whose lungs were well preserved. 10 days later they got the virus! This was the first step into a chain of discoveries and studies that 10 years later would led to sequence its code and thus, the relevant conclusions. This method of building flu-virus particles from pure code is a clever application of the approach to understanding life called "reverse genetics" - that is, looking at a gene to figure out its function, rather than the other way around. But it is not one requiring some spectacular insight or technological breakthrough. The method employs fairly routine molecular biology and was developed independently by two different flu teams, one at Mount Sinai School of Medicine in New York, the other at the University of Wisconsin. The whole story is very interesting and you should read it from the New York Times article "Why revive a Deadly Flu Virus?". Other related articles: http://articles.baltimoresun.com/1999-11-18/news/9911180290_1_similar-flu-influenza-1918-virus http://www.ncbi.nlm.nih.gov/pmc/articles/PMC15547/


Performance meets energy efficiency

It's often believed that performance and energy efficiency are issues that should be balanced in order to achieve a specific result. More and more, in recent years this issue has been addressed to with a different perspective and as a result we see technology break throughs like the BMW i8 sports car: "...the first sports car with the consumption and emission values of a compact car…". We believe the 'new way' of approaching it, instead of suggesting the balance between the two factors, pushes them independently. Performance meets energy efficiency. Unbalanced: Push one to its limits, then push the other. Observe. Repeat. We would like to share an article written by our CEO in which he explains 'our way' and states that with our new technology you don't have to choose between one another. You can have both. Performance meets energy efficiency: they dance, we host. Read the article here.  


New Technology v.s. Dinosaurian Technology

Originally posted by Z-SC1's CEO Jean Fallacara here. Jean is always open to discussion. Connect with him on Linked In here. Today, we have revolutionized our world with amazing technologies. We have reshaped the technology of the past's to make better products, offer more security and give peace of mind. The Stone Age is a broad prehistoric period during which stone was widely used to make implements with a sharp edge, at Z-SC1 we believe that cascade refrigeration systems is also a dinosaurian technology that some manufacturers just try to keep alive (or even reanimate) for obvious financial reason. Matter of fact, the cascade refrigeration technology poorly failed to offer security, and generated billions $ of losses over the last decades. Protection of valuable and oftentimes irreplaceable biospecimens is a critical factor for ensuring valid and reproducible pre-clinical drug development results. Too much damage to important specimens caused by malfunctioning equipment, too much continued vigilance to proper biological specimen storage is required. Due to the obvious divide set between cascade refrigeration and Dual Cooling single compressors, sometimes both generations are forced to meet which commonly results in conflicting ideologies of digital technology. The everyday regime of work life in Science is becoming more technologically advanced with improved computers in offices, more complicated machinery in industry etc. With technology moving so fast it is hard for some manufacturer to keep up. In fact, some things seem so strange to us that we immediately put them out of our minds as being completely wrong.... What the Scientific community think about this, how do you feel about Do you really believe that being Extremely paranoid about your samples inside ULT freezers shall be a justifiable reason You spreads samples across multiple freezers, as a hedge in case of failure.... I don't! ... in all these Research labs, biorepositories, Biobanks... What are You exactly expecting from US and from ALL manufacturers of ULT Freezers?. Definitely Not a sales speech... Only facts, and a simple thing: PEACE OF MINDfor the storage of their high-value samples!


DNA Evidence Testing: Jack the Ripper and Gregory Turner

Aaron Kosminski was identified as  Jack the Ripper by DNA evidence testing. Gregory Turner was bound for life in prison after an RCMP lab reported  a tiny amount of DNA on his gold ring from a murdered woman, but the lab was wrong. Is DNA evidence reliable? It definitely depends. One of the most difficult murder mysteries of all times is solved: the identity of Jack the Ripper. At least that's what an 'amateur sleuth' claims by presenting new DNA evidence from a shawl that was supposedly found at a crime scene 126 years ago. The piece of cloth had blood from the victim and semen from Jack. The investigation was held by Dr Jari Louhelainen in the UK. You can read different versions of this story: Mail Online, Smithsonian Mag. Mr. Turner was convicted to life in prison but he was very lucky to have Mr. Jerome Kennedy as a lawyer: "A lucky hunch by Mr. Kennedy - now Newfoundland's Minister of Health - saved Mr. Turner from a life behind bars. He sought the name and DNA profile of every technician who had worked at the RCMP lab. It turned out that the technician who had tested the ring had also been working on the victim's fingernails a few inches away, creating a strong possibility of contamination." The tester had accidentally contaminated samples in other cases too. Mr. Turner's spent 27 months in jail. Read his story here from The Globe and Mail. DNA evidence depends on many factors but its manipulation and environment may risk its stability. We are no experts in crime scene investigation. If you want to learn a bit about Collection and Preservation of Blood Evidence from Crime Scenes, click here. If you want interesting technology, science and art content, come back soon! Check out this video about the DNA investigation that led to Ripper's identity.  


When Ultra Low Temperature becomes Extreme Low Temperature

Ultra low temperatures. We're just amazed with this universe that is unveiled when we go down the thermometer. Unimaginable processes are possible as predicted by science fiction or really, really smart scientists. In this case, we want to share one of our favorite 'cold' stories about Erick Cornell, Nobel Prize Laureate: "The Nobel Prize in Physics 2001 was awarded jointly to Eric A. Cornell, Wolfgang Ketterle and Carl E. Wieman "for the achievement of Bose-Einstein condensation in dilute gases of alkali atoms, and for early fundamental studies of the properties of the condensates"." The video we are sharing, explained by Cornell himself, illustrates how to achieve the Bose-Einstein condensation, a state of matter in which a diluted gas is brought down near absolute zero. At this point, Quantum effects become apparent. The 'Quantum-world' is of great interest in our everyday life as it is the key to a major leap in computer technology. By implementing Quantum computation, big problems that would take years (that's right, years) to compute in today's machines will be solved in a matter of seconds. If you want more detailed information about this issue, we recommend this Ted Talk video featuring Michelle Simmons at Tedx Sydney. We hope quantum technology arrives in the near future. But for now, we will continue keeping our stable Ultra Low Temperatures..... ultra low. The video is presented by the National Institute of Standards and Technology. We hope you enjoy it.


THERAPEUTIC HYPOTHERMIA: EMBRACING COLD

Heart attack's main risk involves permanent brain damage which is produced by the lack of oxygen to the organ . Many victims wake up looking normal but their brains will never be the same. This interesting story published at The Daily Mail details  the recovery of Mike Burton after the attack. In recent years, cardiologists all over the world have adopted the therapeutic hypothermia treatment which uses "the simplest of technologies: ice" as stated by The Wall Street Journal. The procedure, as described in the article affirms that  "Once a patient's heartbeat is restored, emergency-room doctors, cardiologists and rescue squads are quickly applying ice and other coolants to moderately lower a patient's body temperature by about six degrees. Then the patient is put in a drug-induced coma in intensive care for 24 hours before gradually being warmed back up to normal temperature." And because it's working, many ER facilities have been adopting this treatment, embracing the cold, as we do. We want to share a video from Penn Medicine's Center for Resuscitation Science in which they describe a successful experience with it. We hope you enjoy it.


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